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For a deeper dive into semaglutide specifically, see our companion article, the Semaglutide Research Guide

While our study focused on TCAs at higher doses for depression and identified a 6-fold increase in odds of OH compared to placebo, it is likely that TCAs at lower doses also cause harm, especially in older adults at higher risk of OH due to a decrease in baroreflex sensitivity [32]

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Pharmacokinetics: ADMET of Exenatide The mechanism behind the significant increase in cardiovascular event rates is unknown and requires further study